The 'settlement currency' is the currency that Worldpay will pay you in. This can be different from the 'acceptance currency' which is the currency in which your customer pays you on your website.
Setting up settlement currencies can be done
This video gives an overview of the benefits of Worldpay Online Payments:
This video explains how to sign up for a basic account with Worldpay Online Payments:
This video explains how to activate your Worldpay Online Payments account:
This video explains how to set up telephone orders with Worldpay Online Payments: